期刊
BRAIN RESEARCH
卷 1725, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.brainres.2019.146484
关键词
Astrocytes; Lipid droplet; Lipidomics; Lipotoxicity; Oleic acid
资金
- Japan Society for the Promotion of Science (JSPS) KAKENHI Grant [16K16589, 26860144]
- Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and Development, AMED [17dm0107100h0002]
- Grants-in-Aid for Scientific Research [16K16589, 26860144] Funding Source: KAKEN
Astrocytes exhibit an important role in neural lipid metabolism for the regulation of energy balance to supply fatty acids (FAs) and ketone bodies to other neural cells. Lipid droplets (LDs) consisting of neutral- and phospholipids increase in the brains of patients with neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis. However, the role of LDs and its lipid source remains largely unexplored. Here, we found that oleic acid (OA) was a potent inducer of astrocytic LD accumulation among various FAs. Lipidomic analysis using liquid chromatography equipped with tandem mass spectrometry revealed that the cellular triacylglycerol and phospholipid compositions in astrocytes during LD accumulation reflected the condition of extracellular FAs. Furthermore, the inhibition of diacylglycerol acyltransferase blocked OA-induced LD accumulation and caused lipotoxicity-induced cell death in astrocytes. The present study demonstrated that the formation of LDs, caused due to the increased extracellular OA, facilitated survival against lipotoxic condition.
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