Aging-related differences in the cortical network subserving intelligible speech

Language communication is crucial throughout the lifespan. The current study investigated how aging affects the brain network subserving intelligible speech. Using functional magnetic resonance imaging, we compared brain responses to intelligible and unintelligible speech between older and young adults. Univariate and multivariate analyses revealed reduced brain activation and lower regional pattern distinctions in response to intelligible versus unintelligible speech in the left anterior superior temporal gyrus (aSTG) and the left inferior frontal gyrus (IFG) in the older compared with young adults. Notably, the functional connectivity between the left IFG and the left angular gyrus (AG) was increased and a significantly enhanced bidirectional effective connectivity between the left aSTG and the left AG was observed in the older adults for processing speech intelligibility. Our study revealed aging-related differences in the cortical activity for intelligible speech and suggested that increased frontal-temporal-parietal functional integration may help facilitate spoken language processing in older adults.