期刊
BMC BIOLOGY
卷 18, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12915-020-0743-4
关键词
Coturnix japonica; Quail; Genome; Influenza; Seasonality; Photoperiod; Bird flu
类别
资金
- French Agence Nationale de la Recherche (SNP-BB project) [ANR-009-GENM-008]
- INRAE Genetics Division (QuailAnnot program)
- AGENAVI-ITAVI SeqVol program
- National Health and Medical Research Council
- National Institute of Allergy and Infectious Diseases, National Institutes of Health [HHSN266200700005C, HHSN272201400006C]
- Vallee Foundation
- ALSAC
- HFSP 2015 award [RGP0030/2015]
- [BB/N015347/1]
- BBSRC [BBS/E/D/30002276, BBS/E/D/20211550, BB/M011461/1, BB/N015347/1, BB/S02008X/1] Funding Source: UKRI
Background The Japanese quail (Coturnix japonica) is a popular domestic poultry species and an increasingly significant model species in avian developmental, behavioural and disease research. Results We have produced a high-quality quail genome sequence, spanning 0.93 Gb assigned to 33 chromosomes. In terms of contiguity, assembly statistics, gene content and chromosomal organisation, the quail genome shows high similarity to the chicken genome. We demonstrate the utility of this genome through three diverse applications. First, we identify selection signatures and candidate genes associated with social behaviour in the quail genome, an important agricultural and domestication trait. Second, we investigate the effects and interaction of photoperiod and temperature on the transcriptome of the quail medial basal hypothalamus, revealing key mechanisms of photoperiodism. Finally, we investigate the response of quail to H5N1 influenza infection. In quail lung, many critical immune genes and pathways were downregulated after H5N1 infection, and this may be key to the susceptibility of quail to H5N1. Conclusions We have produced a high-quality genome of the quail which will facilitate further studies into diverse research questions using the quail as a model avian species.
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