期刊
BLOOD REVIEWS
卷 44, 期 -, 页码 -出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.blre.2020.100673
关键词
Microchimerism; Chimerism; Relapse; Allogeneic hematopoietic cell transplantation; Childhood leukemia
类别
资金
- Danish Childhood Cancer Foundation (Denmark) [2018-3695]
- Swedish Childhood Cancer Fund (Sweden) [PR2018-0153]
- Danish Cancer Society (Denmark) [R90-Rp-12807]
Chimerism analysis following hematopoietic stem cell transplantation (HSCT) for leukemia is routinely applied in parallel with quantification of minimal residual disease (MRD) to identify imminent relapse. In the past decades, new methods with a lower limit of detection compared to standard methods have been developed, socalled microchimerism analysis. Microchimerism analysis is fast, simple, applicable across pre-HSCT diseasetype and can be applied on peripheral blood allowing frequent testing during follow-up. Monitoring of microchimerism in blood could replace repeated bone marrow analysis for MRD and allow earlier detection of imminent relapse or graft failure. Clinical studies in single center cohorts have shown conflicting but promising results. There is currently no consensus on the interpretation of microchimerism analysis and heterogeneity of studies remains a major obstacle for inter-study comparisons and meta-analysis in this field. We have conducted a systematic review of studies investigating associations between microchimerism and relapse of leukemia post-HSCT. We summarize current evidence and provide suggestions for future research.
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