期刊
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
卷 67, 期 3, 页码 396-403出版社
WILEY
DOI: 10.1002/bab.1882
关键词
microRNA; RIG-I; viral infection; macrophages
资金
- Hebei key project plan of medical science research [20180597]
- Hebei science and technology support project [132777252]
The host protective immunity against viral infection requires the effective detection of viral antigens and the subsequent production of type I interferons (IFNs) by host immune cells. Retinoic acid-inducible gene I (RIG-I) is the crucial signaling element responsible for sensing viral RNA component and initiating the downstream antiviral signaling pathways, leading to the production of type I IFNs. In this work, we identified microRNA-218 (miR-218) as a new virus-induced miRNA that dampens the expression of RIG-I in mouse and human macrophages, leading to the impaired production of type I IFNs. Interfering miR-218 expression rescued RIG-I-mediated antiviral signaling and thus protected macrophages from viral infection. Hence, our results provide new understanding of miRNA-mediated viral immune evasion and may be potentially useful for the treatment of viral infection in the future.
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