期刊
BIOTECHNOLOGY ADVANCES
卷 37, 期 8, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2019.107452
关键词
Ribozyme; Catalytic RNA; Self-cleavage; Splicing; Synthetic biology; Expression control; Detecting system; Logic circuit; Activity regulation; Gene editing
资金
- National Research Foundation of Korea (NRF) [NRF-2017R1C1B3012050]
- Global Research Laboratory Program - Korea government (Ministry of Science and ICT) [NRF-2016K1A1A2912829]
- Basic Science Research Program - Ministry of Education [2018R1A6A3A11045727]
- National Research Foundation of Korea [2016K1A1A2912829] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ribozymes are functional RNA molecules that can catalyze biochemical reactions. Since the discovery of the first catalytic RNA, various functional ribozymes (e.g., self-cleaving ribozymes, splicing ribozymes, RNase P, etc.) have been uncovered, and their structures and mechanisms have been identified. Ribozymes have the advantage of possessing features of RNA molecules; hence, they are highly applicable for manipulating various biological systems. To fully employ ribozymes in a broad range of biological applications in synthetic biology, a variety of ribozymes have been developed and engineered. Here, we summarize the main features of ribozymes and the methods used for engineering their functions. We also describe the past and recent efforts towards exploiting ribozymes for effective and novel applications in synthetic biology. Based on studies on their significance in biological applications till date, ribozymes are expected to advance technologies in artificial biological systems.
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