期刊
BIOSENSORS & BIOELECTRONICS
卷 156, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2020.112133
关键词
Stretchable biosensor; Microfluidics; Immunodetection; Wearable device; 3D nanostructured impedimetric biosensor
类别
资金
- Basic Science Research Program through the National Research Foundation (NRF) - Ministry of Science, ICT, AMP
- Future Planning [2019R1A6A1A03033215]
- Nano Material Technology Development Program through the National Research Foundation (NRF) - Ministry of Science, ICT, AMP
- Future Planning [NRF-2016M3A7B4910554]
Conformable, wearable biosensor-integrated systems are a promising approach to non-invasive and quantitative on-body detection of biomarkers in body fluids. However, realizing such a system has been slowed by the difficulty of fabricating a soft affinity-based biosensor patch capable of precise on-body fluid handling with minimal wearer intervention and a simple measurement protocol. Herein, we demonstrate a conformable, wearable labon-a-patch (LOP) platform composed of a stretchable, label-free, impedimetric biosensor and a stretchable microfluidic device for on-body detection of the hormone biomarker, cortisol. The all-in-one, stretchable microfluidic device can precisely collect and deliver sweat for cortisol quantitation and offers one-touch operation of reagent delivery for simultaneous electrochemical signal generation and washing. Three-dimensional nanostructuring of the Au working electrode enables the high sensitivity required to detect the pM-levels of cortisol in sweat. Our integrated LOP detected sweat cortisol quantitatively and accurately during exercise. This LOP will open a new horizon for non-invasive, highly sensitive, and quantitative on-body immunodetection for wearable personal diagnostics.
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