期刊
BIOSENSORS & BIOELECTRONICS
卷 148, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2019.111822
关键词
Biopsy; Real-time cancer discrimination; Electrical conductivity sensor; pH sensor; Glucose sensor
类别
资金
- Nano-Convergence Foundation - Ministry of Science and ICT (MSIT, Korea) [R201603110]
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT (MSIT, Korea) [2015R1A5A1037668]
- Ministry of Trade, Industry and Energy (MOTIE, Korea)
- Korea Evaluation Institute of Industrial Technology (KEIT) [R201802610] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2015R1A5A1037668, R201603110] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A biopsy needle integrated with a multi-modal physical/chemical sensor array for electrical conductivity, pH, and glucose concentration measurement was developed. A flexible device with an electrical conductivity sensor, a pH sensor, and a glucose sensor was fabricated on a flexible polyimide substrate with thickness less than 20 mu m. Then, the sensor was directly integrated onto the surface of biopsy needle by attaching with a pressure sensitive adhesive. The performance factors of the sensor were examined, showing that it could properly measure the parameters in the ranges of human body conditions (conductivity = 0.0265 S/m - 1.027 S/m, pH = 6.6-7.4, and glucose concentration = 2 mM-13 mM). The capabilities of dual-modal and multi-modal sensing were demonstrated by tests with a liver cancer mimicking hydrogel phantom, a solution sample, and porcine liver tissue with exchanged parameters by perfusion of the phosphate buffer saline. Based on these results, we expect that the biopsy needle integrated with the multi-modal sensor array could help to increase the accuracy of the image-guided biopsy process by providing the information of tissue types at the needle tip.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据