期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 84, 期 4, 页码 757-763出版社
OXFORD UNIV PRESS
DOI: 10.1080/09168451.2019.1706442
关键词
Microsomal prostaglandin E synthase-1; lung cancer cells; Punica granatum leaves; dehydrohexahydroxydiphenoyl group; anti-inflammation
类别
资金
- JSPS KAKENHI [18K11134]
- Wesco Scientific Promotion Foundation (Okayama, Japan)
- Grants-in-Aid for Scientific Research [18K11134] Funding Source: KAKEN
Prostaglandin E-2 (PGE(2)), which is a potent pro-inflammatory lipid mediator, is biosynthesized from arachidonic acid by cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1). Non-steroidal anti-inflammatory drugs (NSAIDs) are used clinically as COX inhibitors, but they have gastrointestinal and cardiovascular side-effects. Thus, the terminal enzyme mPGES-1 holds promise as the next therapeutic target. In this study, we found that the ellagitannins granatin A and granatin B isolated from pomegranate leaves, and geraniin, which is their structural analog, selectively suppressed mPGES-1 expression without affecting COX-2 in non-small cell lung carcinoma A549 cells. The ellagitannins also down-regulated tumor necrosis factor alpha, inducible nitric oxide synthase, and anti-apoptotic factor B-cell chronic lymphocytic leukemia/lymphoma 2, and induced A549 cells to undergo apoptosis. These findings indicate that the ellagitannins have anti-inflammatory and anti-carcinogenic effects, due to their specific suppression of mPGES-1.
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