期刊
BIOORGANIC CHEMISTRY
卷 96, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2020.103651
关键词
Forsythia suspensa (Thunb) Vahl; Labdane diterpenoids; Forsyshiyanins A-B; Anti-inflammatory; Anti-viral
资金
- Natural Science Foundation of China [21372189]
- Natural Science Foundation of Shandong Province [ZR2019HM091]
Eight labdane diterpenoids, including two new labdane diterpenoids, named forsyshiyanins A-B (2-3), along with six known ones (1, 4-8), were isolated from the fruits of Forsythia suspensa. The new structures including their absolute configurations were elucidated by extensive spectroscopic analyses, X-ray diffraction and computational calculation. In vitro, eight labdane diterpenoids showed anti-inflammatory activities, with the inhibition rates of release of beta-glucuronidase from polymorphonuclear leukocytes of rats being in the range 46.8-51.0% at concentrations of 10 mu M, as well as anti-viral activities against influenza A (H1N1) virus and respiratory syncytial virus (RSV), with the IC50 values in the range 18.4-26.2 mu M and EC50 values in the range 10.5-14.4 mu M, respectively.
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