期刊
BIOORGANIC CHEMISTRY
卷 96, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2020.103630
关键词
Heleocharis dulcis; Flavonoid; Neuroprotective; Hepatoprotective
资金
- Scientific Research Project of Jiangxi Administration of Traditional Chinese Medicine [2019A002, 2019A018]
- National Natural Science Foundation of China [81803843]
- Standard Revision Research Project of National Pharmacopoeia Committee [2018Z090]
- Science and Technology Project of Jiangxi Health Commission [20195648, 20195650]
- Science and Technology Project of Jiangxi Provincial Department of Education [GJJ180662, GJJ180688]
- Scientific Research Project of First-class Discipline of Chinese Materia Medica of Jiangxi University of TCM [JXSYLXK-ZHYAO027, JXSYLXK-ZHYAO032]
- Doctoral Research Initiation Fund Project of Jiangxi University of TCM [2018BSZR007, 2018BSZR010]
Chinese water chestnut, the bulb of Heleocharis dulcis, has been widely consumed as fruit or vegetable in China since ancient times. It exhibits health-promoting properties that leads to an extensive study of their active components. Successive chromatography of active fragments of H. dulcis resulted in isolation of five new chalcone-flavonone heterodimers (1-3, 6, 9), four new diverse flavonoids (4, 5, 7, 8), and sixteen known flavonoids derivatives (10-25) were elucidated on the basis of their IR, UV, NMR, MS spectrometry data analysis and references from H. dulcis for the first time. Among these isolates, compounds 4, 7, 9, 12, 13, and 17 showed moderate neuroprotective activity, which increased the cell survival rate from 49.23 +/- 3.68% for the model to 67.75 +/- 2.75%, 57.83 +/- 2.46%, 67.98 +/- 2.74%, 58.65 +/- 3.43%, 56.14 +/- 1.99%, and 56.70 +/- 1.38% at 10 mu M, respectively. Moreover, compounds 1-3, 15, 16, 18, and 20 were found to moderately improve the HepG2 cell survival rates from 39.53% (APAP, 10 mM) to 45.53-53.44%. The outcome of the study provided crucial information regarding the structural diversity and health benefits of the edible bulbs of H. dulcis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据