期刊
BIOORGANIC CHEMISTRY
卷 93, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2019.103307
关键词
alpha-Glucosidase inhibition activity; Triazolopyrimidines; Multicomponent approach; Molecular docking; ADME studies
资金
- Council of Scientific and Industrial Research (CSIR) [02(0300)/17/EMR-II]
- MHRD, India
- CSIR-IICT Hyderabad Communication [IICT/Pubs/2019/332]
The aim of the present study is to design and synthesis of new pyrazole-triazolopyrimidine hybrids as potent alpha-glucosidase inhibitors. The target compounds 4a-n were synthesized by one-pot multicomponent approach with good yields and were characterized by various spectroscopic techniques and finally by single crystal X-ray diffraction method (4j). All the newly-synthesized derivatives have been screened for their alpha-glucosidase enzyme inhibition activity and acarbose taken as a standard drug. Among all the tested compounds, 4h has displayed excellent alpha-glucosidase enzyme inhibition activity with IC50 value 12.45 mu M to the standard drug acarbose (IC50: 12.68 mu M). Similarly, the compounds 4f and 4l have exhibited potent activity with IC50 values 14.47 mu M and 17.27 mu M respectively. Structure-activity relationship (SAR) studies of all the title compounds were established. The mode of binding interactions between the alpha-glucosidase enzyme and the compounds were studied. The drug-likeness properties (Lipinski parameters and in silico ADME properties) have predicted for the target compounds. The alpha-glucosidase inhibition, molecular docking and drug-likeness properties of the compounds 4h, 4f and 4l were suggested that these are promising hits for anti-diabetic activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据