期刊
BIOORGANIC CHEMISTRY
卷 98, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2020.103697
关键词
Stephania tetrandra; Menispermaceae; Bisbenzylisoquinoline alkaloids; Anti-inflammatory activities; Cytotoxicity
资金
- Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine [CAMS-12M-1-010]
- State Key Laboratory of Bioactive Substance and Function of Natural Medicines [GTZA201803]
- Drug Innovation Major Project [2018ZX09711001-008-009]
Ten new bisbenzylisoquinoline alkaloids (1-10) and eight known analogues (11-18) were obtained from the roots of Stephania tetrandra. The structures of these compounds were determined by spectroscopic methods, single-crystal X-ray diffraction, electronic circular dichroism analyses, and chemical method. Compounds 1, 15, and 16 showed the better anti-inflammatory activities with IC50, values of 15.26 +/- 2.99, 6.12 +/- 0.25, and 5.92 +/- 1.89 mu M, respectively. Compound 18 possessed cytotoxic activities against MCF-7, HCT-116, and HepG2 cell lines with IC50 values of 2.81 +/- 0.06, 3.66 +/- 0.26, and 2.85 +/- 0.15 mu M, respectively.
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