期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 121, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2019.109280
关键词
PSS-loaded nanoparticles; Microcirculation dysfunction; Diabetic cardiomyopathy; Vascular endothelial function; Coagulation; Oxidative stress
资金
- NSFC-Shandong Joint Fund [U1606403]
- Shandong Science and Technology Project [2014GGH215001]
- Qingdao Independent Innovation Project [15-4-13-zdzx-hy]
- National Natural Science Foundation of China (NSFC) [31571829]
- People's Livelihood Science and Technology Project - Qingdao city [15-9-2-75-nsh]
Coronary microvascular dysfunction (CMD) is the pathological basis and pathogenesis of diabetic cardiomyopathy (DCM). Propylene glycol alginate sodium sulfate (PSS) as heparinoid drug has many biological activities. Here, a novel PSS-loaded nanoparticle (PSS-NP) was prepared to study its effect on the CMD of DCM. We used diabetes mellitus rat induced by STZ to establish the CMD model of DCM, and the study was detected by echocardiography, histological analysis, transmission electron microscopy, immunofluorescence staining, enzyme-linked immunosorbent assay, real time-PCR analysis, liquid-chip analysis, western blot analysis and so on. The experimental results suggested that PSS-NP could improve the survival state of rats, cardiac function, myocardial morphology and coronary microcirculation structure disorders, and increase the number of microvessels. In addition, we demonstrated that PSS-NP could alleviate the CMD by improving endothelial function, anticoagulation and antioxidative stress. The outcomes of this study provided new treatment thoughts for the therapy of coronary microcirculation dysfunction in DCM.
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