期刊
BIOMATERIALS
卷 243, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.119937
关键词
Heterojunction; Sulfur vacancies; Interface interaction; Transition metal dichalcogenides; Anti-Bacteria; Wound healing
资金
- National Natural Science Foundation of China [21722703, 31770550]
- 111 program [T2017002]
- Tianjin Natural Science Foundation [18JCYBJC23600, 19JCJQJC62500]
We report a heterojunction Bi2WO6/WS2-x with sulfur vacancies as a broad-spectrum bactericide to efficiently kill Gram-positive and Gram-negative bacteria in vitro and in vivo under visible-light irradiation. Sulfur vacancies in single-layer WS2 make the surface electron-rich. Integration of Bi2WO6 with WS2 enhances the photoelectric activity under visible-light irradiation. Sulfur vacancies promote the generation of radicals and the extraction of membrane phospholipids from bacterial cells. Density functional theory verifies that S vacancies strengthen the interactions between the Bi2WO6/WS2-x surface and H2O, enhancing the generation of center dot OH. Two-dimensional correlation spectroscopy analysis reveals that perturbation of beta-sheet proteins and formation of outer-sphere surface complexes contribute to the high antibacterial capacity. Bi2WO6/WS2-x accelerates the re-epithelializafion and healing of infected wounds in an animal model. Uncommonly, Bi2WO6/WS2-x does not exhibit drug resistance and is biocompatible with human cells. Our results indicate that vacancy-functionalized heterojunction are potentially promising antibacterial agents by regulating the interface interaction between biology and nanomaterials.
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