期刊
BIOMATERIALS
卷 243, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.119934
关键词
NIR-IIa fluorescence imaging; NIR-II photothermal therapy; Bioorthogonal labelling; Theranostic nanoplatform; Precision medicine
资金
- Synergetic Innovation Center for Organic Electronics and Information Displays and Primary Research & Development Plan of Jiangsu Province [BE2016770]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) [YX030003]
- National Natural Science Foundation of China [21604042, 21574064, 21674048]
Application of 1064 nm activatable NIR-IIa fluorescence imaging (FI) and NIR-II photothermal therapy (PTT) results in high-resolution imaging and good deep-tissue therapy, respectively. Combining NIR-IIa FI with NIR-II PTT may allow precise diagnosis guided efficient treatment of deep-tissue tumors. However, designing a 1064 activatable theranostic nanoplatform using a single dye for both NIR-IIa FI and NIR-II PIT is a challenge. Herein, we synthesized squaraine-based semiconducting polymer nanoparticles (PSQPNs-DBCO) that were excited by a 1064 nm laser for precise NIR-IIa fluorescence imaging guided NIR-II PTT treatment. Combined with bloor-thogonal labeling technology, the PSQPNs-DBCO largely accumulated in the tumor section, extremely enhancing signal-to-background ratio (SBR) of imaging and NIR-II PTT efficiency of tumor in live colorectal-bearing animals.
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