期刊
BIOMATERIALS
卷 234, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.119762
关键词
NaxMnWO3 nanorod; MRI contrast agent; Cathodic protection; Photoacoustic imaging; Photothermal therapy
资金
- National Funds for Distinguished Young Scientists [51725202]
- National Natural Science Foundation of China [51872094]
- National Science Foundation for the Young Scientists of China [51702211, 21805090]
- National Key R&D Program of China [2018YFA0107900]
- Key Project of Shanghai Science and Technology Commission [19JC1412000]
- Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong
The stability and safety of magnetic resonance imaging (MRI) contrast agents (CAs) are crucial for accurate diagnosis and real-time monitor of tumor development. Paramagnetic Mn2+ as nonlanthanide metal ion has been widely studied for use in T-1-MRI CAs, but unfortunately, Mn2+ can be oxidized by H2O2 in tumor to nonparamagnetic Mn4+ via a Fenton-like reaction. The concurrent loss of paramagnetism and production of toxic hydroxyl radical (center dot OH) go against the basic requirment of CAs, thus restricting the further development of Mn2+-based CM. Based on the different standard potential of W6+/W5+ (similar to 0.26 V) and Mn4+/Mn2+ (similar to 1.2 V), a cathodic protection strategy was exploited in Mn2+-doped NaxWO3 nanorods (NaxMnWO3), with W5+ as the sacrificial anode and Mn2+ as the protected cathode, to protect Mn2+ from oxidation in tumor for stable MR contrast performance, as well as repress its Fenton-like reaction activity for good biosafety. Moreover, the tungsten bronze crystal structure endows NaxMnWO3 with excellent near-infrared (NIR)-photothennal properties for effective tumor hyperthermia, without effect from the changed oxidation state of W. This cathodic protection strategy offers a new method for the development of reliable and hypotoxic biomaterials for stable imaging and therapeutic applications in clinic.
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