期刊
BIOMATERIALS
卷 232, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2019.119732
关键词
Blood brain barrier; Neurovascular unit; In vitro models; Physiological relevance; Vascular permeability; Drug screening
资金
- National Research Foundation of Korea (NRF) - Korean Government (MSIT) [2018R1A2A3075013]
- Brain Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2016M3C7A1913845]
- Technology Innovation Program - Ministry of Trade, Industry & Energy (MOTE, Korea) [10067787]
- KIST Institutional Program [2E29200, 2V07460]
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2017M3A7B4049850]
- KUKIST School Project
- Korea Evaluation Institute of Industrial Technology (KEIT) [10067787] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [21A20130000016, 2E29200, 2V07830] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Central nervous system (CNS) diseases are emerging as a major issue in an aging society. Although extensive research has focused on the development of CNS drugs, the limited transport of therapeutic agents across the blood-brain barrier (BBB) remains a major challenge. Conventional two-dimensional culture dishes do not recapitulate in vivo physiology and real-time observations of molecular transport are not possible in animal models. Recent advances in engineering techniques have enabled the generation of more physiologically relevant in vitro BBB models, and their applications have expanded from fundamental biological research to practical applications in the pharmaceutical industry. In this article, we provide an overview of recent advances in the development of in vitro BBB models, with a particular focus on the recapitulation of BBB function. The development of biomimetic BBB models is postulated to revolutionize not only fundamental biological studies but also drug screening.
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