期刊
BIOMATERIALS
卷 225, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2019.119515
关键词
Tumor-associated macrophages; Macrophage repolarization; Antigen presentation; Cancer therapy; Immunotherapy; Metastasis
资金
- National Natural Science Foundation of China, China [81930099, 81773664, 81473153, 3100877]
- National Basic Research Program of China, China [2015C8755504]
- 111 Project from the Ministry of Education of China
- State Administration of Foreign Expert Affairs of China, China [111-2-07, B17047]
- Open Project of State Key Laboratory of Natural Medicines, China [SKLNMZZCX201811]
- Double First-Class University project, China [CPU2018GY47, CPU2018GF10]
- Fundamental Research Funds for the Central Universities, China [2632019ZD10]
- Natural Science Foundation of Jiangsu Province, China [BK20170747]
Tumor-associated macrophages (TAMs) are abundant in many cancers, and predominately display an immunosuppressive M2-like function that fosters tumor progression and promotes malignant metastasis. Current TAMs repolarization strategies mainly focused on harnessing the direct cancer cell killing property of M1-like macrophages repolarized from TAMs. However, the latent role of Ml-like macrophages as professional antigen-presenting cells (APCs) also needs to be explored. Here, iron chelated melanin-like nanoparticles (Fe@PDA-PEG) were developed for M2-to-M1 TAMs repolarization and photothermal therapy (PTT) induced tumor-associated antigens (TAAs) releasing, which would exploit the potential of M1-like macrophages acquired as professional APCs for TAAs presentation. The results showed that M1 macrophages repolarized from TAMs by Fe@PDA-PEG could capture, process and present TAAs released by PTT through the major histocompatibility complex class II (MHC II) pathway, recruiting T-helper cells and effector T cells in tumor site, which leads to the controlled tumor growth and limited malignant metastasis.
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