期刊
BIOMARKERS IN MEDICINE
卷 14, 期 3, 页码 185-199出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2019-0476
关键词
bioinformatics; biomarker; cancer microenvironment; co-expression networks; fatty acid synthase (FASN); gastric cancer (GC); immune; prognosis; TCGA; tumor-infiltrating
资金
- Natural Science Foundation of Hunan Province [2019JJ40490]
- Clinical Research Project of Xiangya Hospital [2016L06]
Aim: Fatty acid synthase (FASN), a key enzyme for de novo synthesis of fatty acids, has been identified as an oncogene in some tumor types; however, the function of FASN in gastric cancer (GC) is poorly elucidated. Method: Integrative bioinformatics analyses were performed to unveil the role of FASN in tumor progression and cancer-associated immunology of GC. Result:FASN was overexpressed in the GC tissues and correlated with an inferior survival outcome, and largely contributed to the carcinogenesis of GC. Moreover, FASN expression was closely associated with the immune-infiltrating levels of CD8(+) T, CD4(+) T, neutrophils, macrophages and dendritic cells. Conclusion:FASN was closely associated with GC and may be involved in the tumorigenesis and cancer-immune interactions, and could be a promising prognostic and therapeutic biomarker in GC.
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