Evaluation of homocysteine in the diagnosis and prognosis of coronary slow flow syndrome

Aim: To identify the exact molecular markers related to coronary slow flow syndrome (CSFS) and its prognosis. Patients & methods: Data from 54 patients with CSFS diagnosed by coronary angiography and 101 normal control patients were collected and analyzed. Results: Logistic regression analysis confirmed that homocysteine (Hcy; odds ratio: 1.107; 95% CI: 1.018-1.205; p = 0.018) was associated with CSFS. Receiver-operating characteristic curve analysis identified an Hcy value of 17.1 mu mol/l as an effective cut-off point for predicting CSFS. Cox survival analysis showed a relationship between high admission Hcy level (odds ratio: 1.19; 95% CI = 1.05-1.34; p = 0.005) and recurrent angina. Conclusion: Our results showed positive correlations of Hcy with CSFS and cardiac events.