期刊
BIOLOGICAL PSYCHIATRY
卷 87, 期 1, 页码 64-73出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2019.10.018
关键词
Depression; fMRI; Nucleus accumbens; Opioid addiction; Pain circuitry; Prefrontal cortex
资金
- National Institute of Neurological Disorders and Stroke [NS086444, NS093537]
- National Institute on Drug Abuse [PPG-POIDAO8227, T32 5T32DA007135-34]
Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive, and affective symptoms. Over the past 2 decades, researchers have made significant progress toward understanding the impact of mesolimbic dopamine circuitry in acute and chronic pain. These efforts have provided insights into the circuits and intracellular pathways in the brain reward center that are implicated in sensory and affective manifestations of chronic pain. Studies have also identified novel therapeutic targets as well as factors that affect treatment responsiveness. Dysregulation of dopamine function in the brain reward center may further promote comorbid mood disorders and vulnerability to addiction. This review discusses recent clinical and preclinical findings on the neuroanatomical and neurochemical adaptations triggered by prolonged pain states in the brain reward pathway. Furthermore, this discussion highlights evidence of mechanisms underlying comorbidities among pain, depression, and addiction.
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