期刊
BIOLOGICAL PSYCHIATRY
卷 88, 期 7, 页码 541-553出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2020.02.008
关键词
Chronic stress; Goal-directed behavior; Prefrontal cortex; Pyramidal neurons; Reward; Social defeat
资金
- National Institutes of Health [R01MH112750, R21MH118596, R01MH077681, DP1DA050986]
- Brain & Behavior Research Foundation Young Investigator Grant
- Howard Hughes Medical Institute Medical Research Fellowship
- National Institutes of Health Training Grant [T32NS041228]
- National Science Foundation Graduate Research Fellowship [DGE-1122492]
- Alzheimer's Association Research Fellowship [AARF-17-504924]
BACKGROUND: When exposed to chronic social stress, animals display behavioral changes that are relevant to depressive-like phenotypes. However, the cascading relationship between incremental stress exposure and neural dysfunctions over time remains incompletely understood. METHODS: We characterized the longitudinal effect of social defeat on goal-directed actions and prefrontal cortical activity in mice using a novel head-fixed sucrose preference task and two-photon calcium imaging. RESULTS: Behaviorally, stress-induced loss of reward sensitivity intensifies over days. Motivational anhedonia, the failure to translate positive reinforcements into future actions, requires multiple sessions of stress exposure to become fully established. For neural activity, individual layer 2/3 pyramidal neurons in the cingulate and medial secondary motor subregions of the medial prefrontal cortex have heterogeneous responses to stress. Changes in ensemble activity differ significantly between susceptible and resilient mice after the first defeat session and continue to diverge following successive stress episodes before reaching persistent abnormal levels. CONCLUSIONS: Collectively, these results demonstrate that the cumulative impact of an ethologically relevant stress can be observed at the level of cellular activity of individual prefrontal neurons. The distinct neural responses associated with resilience versus susceptibility suggests the hypothesis that the negative impact of social stress is neutralized in resilient animals, in part through an adaptive reorganization of prefrontal cortical activity.
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