期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 43, 期 1, 页码 179-183出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b19-00564
关键词
quorum sensing inhibitor; Pseudomonas aeruginosa; actinomycete metabolite library
资金
- Private University Research Branding Project from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
Quorum sensing (QS) is a microbial signaling system that regulates the expression of many virulence genes. Herein, we studied five compounds-No. 1: (E)-2-methyl-3- (4-nitro-phenyl)-acrylaldehyde; No. 29-2: pimprinine [5-(1H-indo1-3-yl)-2-methyloxazole]; No. 48: (2E,4E)-2-methyl-5-phenyl-2,4-pentadienoic acid; No. 74: (3E,5E)-5-methyl-6-(4-nitrophenyl)-hexa-3,5-dien-2-ol; and No. 130: methyphenazine-1-carboxylate-derived from an actinomycete metabolite library. These compounds were confirmed to be QS inhibitors that reduced violacein production in Chromobacterium violaceum CV026. Additionally, compounds No. 1, No. 74, and No. 130 significantly reduced fluorescent pigment production in Pseudomonas aeruginosa ATCC 27853.
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