期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1873, 期 1, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbcan.2019.188326
关键词
Pancreatic cancer; Type 2 diabetes; Obesity; Inflammation; Exosomes
资金
- Avner Pancreatic Cancer Foundation grant
- Curtin University Health Sciences Faculty International Research Scholarships
Pancreatic cancer is one of the leading determinants of global cancer mortality, and its incidence is predicted to increase, to become in 2030 the second most common cause of cancer-related death. Obesity and diabetes are recognized risk factors for the development of pancreatic cancer. In the last few decades an epidemic of diabetes and obesity has been spreading worldwide, forewarning an increase in incidence of pancreatic cancer. This review considers the most recent literature, covering the multiple molecular axis linking these three pathologies, aiming to draw a more comprehensive view of pancreatic cancer for a better theragnostic stratification of the population.
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