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The intricate relationship between diabetes, obesity and pancreatic cancer

期刊

出版社

ELSEVIER
DOI: 10.1016/j.bbcan.2019.188326

关键词

Pancreatic cancer; Type 2 diabetes; Obesity; Inflammation; Exosomes

资金

  1. Avner Pancreatic Cancer Foundation grant
  2. Curtin University Health Sciences Faculty International Research Scholarships

向作者/读者索取更多资源

Pancreatic cancer is one of the leading determinants of global cancer mortality, and its incidence is predicted to increase, to become in 2030 the second most common cause of cancer-related death. Obesity and diabetes are recognized risk factors for the development of pancreatic cancer. In the last few decades an epidemic of diabetes and obesity has been spreading worldwide, forewarning an increase in incidence of pancreatic cancer. This review considers the most recent literature, covering the multiple molecular axis linking these three pathologies, aiming to draw a more comprehensive view of pancreatic cancer for a better theragnostic stratification of the population.

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