期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1873, 期 1, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbcan.2019.188316
关键词
Cancer; Chronic disease; LncRNA; NF-kappa B; Non-coding RNA
资金
- Science and Engineering Research Board [ECR/2016/000034]
- University Grants Commission [30-112/2015 (BSR)]
- NIH/NCI [K22CA197074-01]
- Leukemia Research Foundation
- Nebraska State DHHS [LB506]
- UNMC Pediatric Cancer Research Center
- Fred and Pamela Buffett Cancer Center's pilot grant [P30 CA036727]
- Department of Biochemistry and Molecular Biology start-up
- Indian Council of Medical Research, Government of India [5/3/8/40/ITR-F/2019-ITR, 3/2/2/43/2018/Online Onco Fship/NCD-III]
The regulation of the pleiotropic transcription factor, nuclear factor-kappa B (NF-kappa B) by miRNAs and proteins is extensively studied. More recently, the NF-kappa B signaling was also reported to be regulated by several long noncoding RNAs (lncRNAs) that constitute the major portion of the noncoding component of the human genome. The common NF-kappa B associated lncRNAs include NKILA, HOTAIR, MALAT1, ANRIL, Lethe, MIR31HG, and PACER. The lncRNA and NF-kappa B signaling crosstalk during cancer and other diseases such as cardiomyopathy, celiac disease, cerebral infarction, chronic kidney disease, diabetes mellitus, Kawasaki disease, pregnancy loss, and rheumatoid arthritis. Some NE-kappa B related lncRNAs can affect gene expression without modulating NE-kappa B signaling. Most of the lncRNAs with a potential to modulate NF-kappa B signaling are regulated by NF-kappa B itself suggesting a feedback regulation. The discovery of lncRNAs have provided a new type of regulation for the NF kappa B signaling and thus could be explored for therapeutic interventions. The manner in which LncRNA and NF-kappa B crosstalk affects human pathophysiology is discussed in this review. The challenges associated with the therapeutic interventions of this crosstalk are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据