期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1868, 期 1, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbapap.2019.140302
关键词
Endolysin; Enzyme engineering; Catalytic mechanism; Protein structure; Antibacterial
资金
- UC/ESR Connect scholarship
- ESR Strategic Science Initiatives Funding (SSIF) [T-200-4-1]
- New Zealand Royal Society Marsden Fund [U0C1506]
- Ministry of Business, Innovation and Employment Smart Ideas grant [UOCX1706]
- Biomolecular Interactions Centre (University of Canterbury)
Bacteriophage endolysins have the potential to be a long-term antibacterial replacement for antibiotics. The exogenous application of endolysins on some bacteria results in rapid cell lysis. The prospects for endolysins are furthered by the ability to engineer them; novel endolysins can be developed with optimised stability, specificity, and lytic function. But the success of endolysin engineering and application requires a comprehensive understanding of the relationship between the enzymes biochemical, biophysical and bacteriolytic properties. Here, we examine their catalytic mechanisms, opportunities for developing novel endolysins, and highlight areas where a better understanding would support their long-term success as antibacterial agents.
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