期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 15, 期 -, 页码 2941-2947出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.15.289
关键词
aromatic polyketide; Fusarium; marine fungus; secondary metabolite; sponge
资金
- Ministry of Research, Technology and Higher Education, Republic Indonesia through Program Pendidikan Magister Menuju Doktor Untuk Sarjana Unggul (PMDSU) scheme [315-06/UN7.5.1/PP/2017]
- Peningkatan Kualitas Publikasi Internasional (PKPI) scheme
In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A (1) and B (2) and five known compounds (3-7) were isolated from sponge-associated Fusarium sp. KJMT.FP.4.3 which was collected from an Indonesian sponge Xestospongia sp. The structures of these compounds were determined by the analysis of NMR and MS spectroscopic data. The NMR assignment of 1 was assisted by DFT-based theoretical chemical shift calculation. Compound 2 showed antibacterial activity against multidrug resistant Salmonella enterica ser. Typhi with a MIC of 125 mu g/mL while 1 was not active.
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