期刊
BEHAVIOURAL BRAIN RESEARCH
卷 379, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbr.2019.112346
关键词
Adult neurogenesis; Pattern separation; Dentate gyrus
资金
- National Institutes of Health [R37NS047344, R35NS097370]
- University of Pennsylvania (URF)
Hypotheses about the functional properties of the dentate gyrus and adult dentate neurogenesis have been shaped by early observations of the anatomy of this region, mostly in rodents. This has led to the development of a few core propositions that have guided research over the past several years, including the predicted role of this region in pattern separation and the local transformation of inputs from the entorhinal cortex. We now have the opportunity to review these predictions and update these anatomical observations based on recently developed techniques that reveal the complex structure, connectivity, and dynamic properties of distinct cell populations in the dentate gyrus at a higher resolution. Cumulative evidence suggests that the dentate gyrus and adult-born granule cells play a role in some forms of behavioral discriminations, but there are still many unanswered questions about how the dentate gyrus processes information to support the disambiguation of stimuli.
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