期刊
AUTOPHAGY
卷 16, 期 12, 页码 2140-2155出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2020.1717128
关键词
Apoptotic bodies; autophagy; lysosome; mesenchymal stem cell; myocardial infarction
类别
资金
- National Key Research and Development Program of China [2016YFC1101400]
- Young Elite Scientist Sponsorship Program by CAST [2017QNRC001]
- National Natural Science Foundation of China [31800817, 81670915, 31870970]
- Natural Science Basic Research Program of Shaanxi [2018JM3026]
Mesenchymal stem cell (MSC) transplantation has been widely applied as a potential therapeutic for multiple diseases. However, the underlying therapeutic mechanisms are not fully understood, especially the paradox between the low survival rate of transplanted cells and the beneficial therapeutic effects generated by these cells. Herein, in a myocardial infarction (MI) model, we found that transplanted MSCs released apoptotic bodies (ABs) to enhance angiogenesis and improve cardiac functional recovery via regulating macroautophagy/autophagy in the recipient endothelial cells (ECs). Mechanistically, after local transplantation, MSCs underwent extensive apoptosis in the short term and released ABs, which were engulfed by the recipient ECs. Then, in the ECs, ABs activated lysosome functions and promoted the expression of TFEB (transcription factor EB), which is a master gene in lysosomal biogenesis and autophagy. Finally, the increase in TFEB enhanced autophagy-related gene expression in ECs and promoted angiogenesis and cardiac functional recovery after MI. Collectively, we found that apoptotic donor MSCs promote angiogenesis via regulating autophagy in the recipient ECs, unveiling the role of donor cell apoptosis in the therapeutic effects generated by cell transplantation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据