期刊
BMC MOLECULAR BIOLOGY
卷 17, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12867-016-0073-9
关键词
Nucleophosmin 1; DNA repair; Cancer; Apoptosis
资金
- NHMRC [1066550, 1091589]
- ARC [DP 120103099]
- Queensland Health Senior Clinical Research Fellowship
- Advance Queensland Research Fellowship
- National Health and Medical Research Council of Australia [1066550, 1091589] Funding Source: NHMRC
Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a protooncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据