期刊
ARCHIV DER PHARMAZIE
卷 353, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.201900350
关键词
antimalarial; antiplasmodial; chalcone; hybrid compounds; structure-activity relationship
资金
- Shandong Provincial Health Department [2017WS102]
- Open Research Fund of Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention [2017KEYLAB04]
- Academic Promotion Programme of Shandong First Medical University
- Key Research and Development Program of Shandong Province [2018GSF118092, 2019GSF111006]
- Innovation Project of Shandong Academy of Medical Sciences
Malaria, one of the most striking, re-emerging infectious diseases caused by the genus Plasmodium, places a huge burden on global healthcare systems. A major challenge in the control and eradication of malaria is the continuous emergence of increasingly widespread drug-resistant malaria, creating an urgent need to develop novel antimalarial agents. Chalcone derivatives are ubiquitous in nature and have become indispensable units in medicinal chemistry applications due to their diverse biological profiles. Many chalcone derivatives demonstrate potential in vitro and in vivo antimalarial activity, so chalcone could be a useful template for the development of novel antimalarial agents. This review covers the recent development of chalcone hybrids as antimalarial agents. The critical aspects of the design and structure-activity relationship of these compounds are also discussed.
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