期刊
AQUACULTURE
卷 515, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.aquaculture.2019.734571
关键词
LAB-Fermented selenium; Growth performance; Immunity; Nile tilapia; Oxidative status
资金
- project Biological production of nanoselenium spheres and its application in livestock production by the National Strategy for Genetic Engineering and Biotechnology, Academy of Scientific Research and Technology, Egypt
The present study was conducted to investigate the effects of lactic acid bacteria-produced nanoselenium spheres (LAB-Se) on the growth performance, blood health, oxidative status and immune-related gene expression in Nile tilapia (initial weight, 14.03 +/- 0.04 g). LAB-Se was incorporated into the basal diet at 0.5, 1, 1.5 and 2 mg/kg of diet and fed to the fish for 8 weeks. The results revealed significantly improved final body weights, weight gain, specific growth rates and feed efficiency ratios in fish fed varying levels of LAB-Se (quadratic, P = 0.002, P = 0.002, P = 0.002, and P = 0.04, respectively). The blood haematology and biochemistry parameters of the fish fed varying levels of LAB-Se showed normal values with nonsignificant (P > 0.05) differences, indicating the non-toxic effect of LAB-Se. Additionally, dietary LAB-Se had significant influences on blood total protein and lysozyme and phagocytic activities in tilapia in a dose-dependent manner (quadratic, P = 0.04, P = 0.02, and P = 0.001, respectively). Dietary LAB-Se significantly increased SOD and CAT enzyme activities and decreased MDA levels (quadratic, P = 0.001, P = 0.03, and P = 0.007, respectively); GPX was not significantly affected by LAB-Se inclusion the diets (P > 0.05). Liver and spleen TNF-alpha expression was significantly upregulated in the fish fed LAB-Se (quadratic, P = 0.007 and P = 0.009, respectively). The expression of liver IL-1 beta was also upregulated significantly in the fish fed LAB-Se (quadratic, P = 0.005), while spleen IL-1 beta was not significantly affected by LAB-Se (P > 0.05). Thus, LAB-Se at 1 to 2 mg/kg can be effectively supplemented in tilapia diets to improve growth, oxidative status and immune-related gene expression.
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