4.8 Review

Maternal antenatal multiple micronutrient supplementation for long-term health benefits in children: a systematic review and meta-analysis

期刊

BMC MEDICINE
卷 14, 期 -, 页码 -

出版社

BMC
DOI: 10.1186/s12916-016-0633-3

关键词

Child; Micronutrients; Prenatal exposure delayed effects

资金

  1. National Institute of Health Research
  2. Wellcome Trust [091561/Z/10/Z]
  3. Sitaram Bhartia Institute of Science and Research, New Delhi
  4. Medical Research Council and Department for International Development
  5. Wellcome Trust [091561/Z/10/Z] Funding Source: Wellcome Trust
  6. MRC [MC_UP_A620_1016, MC_UU_12011/3, G0400519] Funding Source: UKRI
  7. Medical Research Council [U1475000003, MC_UP_A620_1016, MC_UU_12011/3, G0400519] Funding Source: researchfish
  8. National Institute for Health Research [ACF-2007-18-008, CL-2015-18-004] Funding Source: researchfish

向作者/读者索取更多资源

Background: Multiple micronutrient supplementation for pregnant women reduces low birth weight and has been recommended in low- and middle-income countries (LMICs) to improve child survival, growth and health. We aimed to review the evidence from long-term follow-up studies of multiple micronutrient supplementation beginning in the later first or second trimester. Methods: We searched systematically for follow-up reports from all trials in a 2015 Cochrane review of multiple micronutrient supplementation in pregnancy. The intervention comprised three or more micronutrients and the comparison group received iron (60 mg) and folic acid (400 mu g), where possible. Median gestation of commencement varied from 9 to 23 weeks. Primary outcomes were offspring mortality, height, weight and head circumference, presented as unadjusted differences in means or proportions (intervention minus control). Secondary outcomes included other anthropometry, body composition, blood pressure, and cognitive and lung function. Results: We found 20 follow-up reports from nine trials (including 88,057 women recruited), six of which used the UNIMMAP supplement designed to provide recommended daily allowances. The age of follow-up ranged from 0 to 9 years. Data for mortality estimates were available from all trials. Meta-analysis showed no difference in mortality (risk difference -0.05 per 1000 livebirths; 95 % CI, -5.25 to 5.15). Six trials investigated anthropometry and found no difference at follow-up in weight-for-age z score (0.02; 95 % CI, -0.03 to 0.07), height-for-age z score (0.01; 95 % CI, -0.04 to 0.06), or head circumference (0.11 cm; 95 % CI, -0.03 to 0.26). No differences were seen in body composition, blood pressure, or respiratory outcomes. No consistent differences were seen in cognitive function scores. Conclusions: There is currently no evidence that, compared with iron and folic acid supplementation, routine maternal antenatal multiple micronutrient supplementation improves childhood survival, growth, body composition, blood pressure, respiratory or cognitive outcomes.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据