期刊
APPLIED ORGANOMETALLIC CHEMISTRY
卷 34, 期 5, 页码 -出版社
WILEY
DOI: 10.1002/aoc.5574
关键词
antibacterial; anticancer; Croton sparsiflorus; gold nanoparticles; UV-protection
资金
- UGC-Innovative [F. 14-13/2013 (Inno/ASIST)]
- DST-FIST [SR/FST/LSI-667/2016(C)]
- DST PURSE [SR/PURSE Phase 2/38 (G)]
- MHRD-RUSA 2.0 [F.24/51/2014-jU]
- Faculty of Pharmacy-Jordan [467/34/100 PU]
- Philadelphia University-Jordan [467/34/100 PU]
Our study reports greener synthesis of gold nanoparticles (AuNPs) tethered to the extract of Croton sparsiflorus and in vitro evaluation of UV-protection, antibacterial and anticancer activities. Sophisticated instrumental analytical techniques such as UV-vis spectrophotometer, FT-IR, XRD, FE-SEM, and TEM were employed for the existence and confirmation of the nanoparticles. FT-IR and HPLC analysis were executed in the identification of the plausible functional groups implicated in the reduction of gold ions to AuNPs. UV protection property and antibacterial action of AuNPs-coated cotton fabric were also presented. Moreover, in vitro anticancer evaluation against HepG2 cell line was conducted by MTT assay for Croton sparsiflorus extract derived AuNPs in different concentrations (50 to 150 mu g/ml). Thus, the results of this work revealed that greener synthesized AuNPs exhibited good therapeutic applications as UV-protection, antibacterial and anticancer agents.
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