期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 104, 期 4, 页码 1533-1543出版社
SPRINGER
DOI: 10.1007/s00253-019-10217-2
关键词
Abyssomicin; Proximicin; Marine-derived Verrucosispora sp; OSMAC; Anti-influenza A virus
资金
- National Natural Science Foundation of China [21877038, 31720103901, 31430002] Funding Source: Medline
Marine microorganisms live in dramatically different environments and have attracted much attention for their structurally unique natural products with potential strong biological activity. Based on the one strain-many compounds (OSMAC) strategy and liquid chromatography mass spectrometry (LC-MS) methods, our continuing efforts on the investigation of novel active compounds from marine Verrucosispora sp. MS100137 has led to the identification of a new polycyclic metabolite, abyssomicin Y (1), together with six known abyssomicin and proximicin analogs (2-7). Abyssomicin Y is a type I abyssomicin with an epoxide group at C-8 and C-9. Compounds 1-3 showed potent inhibitory effects against the influenza A virus; their observed inhibition rates were 97.9%, 98.3%, and 95.9%, respectively, at a concentration of 10 mu M, and they displayed lower cytotoxicity than 4. The structures were determined by different NMR techniques and HRMS experiments. This investigation revealed that OSMAC could serve as a useful method for enabling the activation of the silent genes in the microorganism and for the formation of previously unreported active secondary metabolites.
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