期刊
APPLIED CLAY SCIENCE
卷 186, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.clay.2020.105436
关键词
Natural minerals; Ulcerative colitis; Therapy; In vivo evaluation; Drug
资金
- National Natural Science Foundation of China [41572036]
- National Science Fund for Distinguished Young Scholars [51225403]
- Strategic Priority Research Program of Central South University [ZLXD2017005]
- Hunan Provincial Science and Technology Project [2016RS2004, 2015TP1006, 2018WK4023]
- Key R&D Program of Hunan Province [2017GK2251]
- Changsha Science and Technology Project [KC1702029]
- Hunan Provincial Co-Innovation Centre for the Clean and Efficient Utilization of Strategic Metal Mineral Resources [2014-405]
Ulcerative colitis (UC) affects millions of people worldwide and is currently incurable. As such, there is an urgent need for effective drugs that will promote UC remission. This study investigated the therapeutic effects of five typical natural minerals on UC induced by dextran sulfate sodium (DSS): kaolinite (Kaol), halloysite (Hal), diatomite (Dia), montmorillonite (Mt), and palygorskite (Pal). These minerals were characterized by lamellar, tubular, columnar porous, and fibrous morphologies, as well as centered size distribution and negative charge. In vivo experiments indicated that natural minerals had a remission effect on UC and altered gut flora, especially Kaol. These results suggest that natural minerals can serve as drugs, or drug carriers, to attain synergistic effects with other drugs for UC therapy.
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