期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 33, 期 12, 页码 860-881出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2020.8051
关键词
cysteine; glutathione; metastasis; mitochondria; nanoparticles; oxidative stress
资金
- Andalusian Regional Ministry of Health-Fundacion Progreso y Salud
- University of Granada
Recent Advances: New ways of modulating specific and little explored aspects of redox biology have been revealed, as well as new delivery methods or uses of previously known treatments against cancer. Here, we review the latest experimental evidence regarding redox biology in cancer treatment and analyze its potential impact in the development of improved and more effective antineoplastic therapies. Critical Issues: A critical issue that deserves particular attention is the understanding that both extremes of redox biology (i.e., oxidative stress [OS] and reductive stress) might be useful or harmful in relation to cancer prevention and treatment. Future Directions: Additional research is needed to understand how to selectively induce reductive or OS adequately to avoid cancer proliferation or to induce cancer cell death.
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