期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 64, 期 5, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00168-20
关键词
beta-lactam; beta-lactamase inhibitor; antimicrobial stewardship; fixed-dose antibiotic combinations; irrational combinations; unorthodox combinations
In India and China, indigenous drug manufacturers market arbitrarily combined parenteral beta-lactam and beta-lactamase inhibitors (BL-BLIs). In these fixed-dose combinations, sulbactam or tazobactam is indiscriminately combined with parenteral cephalosporins, with BLI doses kept in ratios similar to those for the approved BL-BLIs. Such combinations have been introduced into clinical practice without mandatory drug development studies involving pharmacokinetic/pharmacodynamic, safety, and efficacy assessments being undertaken. Such unorthodox combinations compromise clinical outcomes and also potentially contribute to resistance development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据