期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 64, 期 5, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02303-19
关键词
tedizolid; daptomycin; E. faecalis; E. faecium; MRSA/VRSA; experimental endocarditis; enterococci; staphylococci
资金
- Merck, Inc.
- NIAID [R21AI133289-01A1]
- [K24-AI121296]
- [R01AI134637]
- [R21AI143229]
Tedizolid (TZD) and daptomycin (DAP) were assessed in a rat endocarditis model against Enterococcus faecalis, Enterococcus faecium (resistant to vancomycin and ampicillin), and Staphylococcus aureus. As a monotherapy, TZD for 5 days was not effective in a comparison with no-treatment controls, while DAP for 5 days was significantly effective against these bacteria. Step-down therapy (DAP for 3 days followed by TZD for 2 days) was as effective as DAP for 5 days and was comparable to 3 days of DAP plus ceftriaxone against all bacteria and to 3 days of DAP plus gentamicin against E. faecalis OG1RF.
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