期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 64, 期 3, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01593-19
关键词
MRSA; agr; combination therapy; daptomycin; endocarditis; fitness
资金
- Wayne State University College of Pharmacy and Health Sciences, Department of Pharmacy Practice
- Research Scholars program at the Wayne State University College of Pharmacy and Health Sciences
- NIH NIAID [1-U01-AI124316-01]
We present a case of endocarditis wherein organisms cultured from different valve leaflets yielded different daptomycin susceptibilities from each other and from organisms obtained from peripheral blood culture. Genomic analyses showed mutations in mprF, purR, and agrA. Pharmacokinetic simulations showed consistent activity of daptomycin plus beta-lactam against all subpopulations. This represents an opportunity to understand S. aureus evolution and fitness in vivo on daptomycin therapy and the role of beta- lactams to prevent the selection of daptomycin- resistant subpopulations.
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