期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 64, 期 4, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02453-19
关键词
antiretrovirals; bariatric surgery; obesity; sleeve gastrectomy
Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gas-trectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased similar to 12-fold. Several mechanistic explanations for these findings are discussed.
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