期刊
ANTICANCER RESEARCH
卷 40, 期 3, 页码 1543-1550出版社
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.14100
关键词
Epithelial ovarian cancer; primary debulking surgery; chemotherapy; paclitaxel; carboplatin; bevacizumab; complete response; recurrence
类别
Background/Aim: The aim of the study was to assess the outcome of advanced ovarian cancer patients who i) underwent primary surgery followed by carboplatin/paclitaxel-based chemotherapy with or without bevacizumab, ii) were in complete response after chemotherapy, iii) and subsequently recurred. Patients and Methods: The hospital records of 138 complete responders after chemotherapy with (n=58) or without (n=80) bevacizumab were reviewed. Results: Both survival after recurrence and overall survival were related to age (<= 61 vs. >61 years, p=0.002 and p=0.0001), performance status (0 vs. >= 1, p=0.002 and p=0.001), histotype (serous vs. non serous, p=0.005 and p=0.01), time to recurrence (>= 12 vs. <12 months, p<0.0001 and p<0.0001) and treatment at recurrence (surgery plus chemotherapy vs. chemotherapy, p=0.01 and p=0.004), but not to first-line treatment. Conclusion: This investigation failed to detect a more aggressive behavior of recurrent ovarian cancer after bevacizumab-containing primary treatment.
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