期刊
ANNUAL REVIEW OF GENETICS, VOL 53
卷 53, 期 -, 页码 67-+出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-120116-024603
关键词
myoblast fusion; cell-cell fusion; Drosophila genetics; asymmetric fusogenic synapse; actin-propelled membrane protrusions; mechanosensory response; mechanical tension
资金
- National Institutes of Health [R01 AR053173, R01 GM098816]
- American Heart Association Established Investigator Award
- Howard Hughes Medical Institute Faculty Scholar Award
- Canadian Institute of Health Research postdoctoral fellowship
Cell-cell fusion is indispensable for creating life and building syncytial tissues and organs. Ever since the discovery of cell-cell fusion, how cells join together to form zygotes and multinucleated syncytia has remained a fundamental question in cell and developmental biology. In the past two decades, Drosophila myoblast fusion has been used as a powerful genetic model to unravel mechanisms underlying cell-cell fusion in vivo. Many evolutionarily conserved fusion-promoting factors have been identified and so has a surprising and conserved cellular mechanism. In this review, we revisit key findings in Drosophila myoblast fusion and highlight the critical roles of cellular invasion and resistance in driving cell membrane fusion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据