期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89
卷 89, 期 -, 页码 235-253出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-120219-103641
关键词
Polycomb; Trithorax; bivalent chromatin; gene regulation; epigenetics
资金
- National Institutes of Health (NIH) [R35GM126944]
- Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH
Predicting regulatory potential from primary DNA sequences or transcription factor binding patterns is not possible. However, the annotation of the genome by chromatin proteins, histone modifications, and differential compaction is largely sufficient to reveal the locations of genes and their differential activity states. The Polycomb Group (PcG) and Trithorax Group (TrxG) proteins are the central players in this cell type-specific chromatin organization. PcG function was originally viewed as being solely repressive and irreversible, as observed at the homeotic loci in flies and mammals. However, it is now clear that modular and reversible PcG function is essential at most developmental genes. Focusing mainly on recent advances, we review evidence for how PcG and TrxG patterns change dynamically during cell type transitions. The ability to implement cell type-specific transcriptional programming with exquisite fidelity is essential for normal development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据