期刊
ANNALS OF SURGERY
卷 271, 期 3, 页码 519-526出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SLA.0000000000003012
关键词
colon cancer; complete mesocolic excision; outcome; safety; survival
类别
资金
- Specialized Research Fund for the Science and Technology Project of Beijing [Z161100000516104]
- Doctoral Program of Higher Education [20130001120064]
- Capital Health Development Research Project [TG-2015-002]
Objective: The aim of the study was to evaluate the oncological outcomes of complete mesocolic excision (CME) in colon cancer patients. Summary Background Data: CME is considered a standard procedure for colon cancer patients. However, previous evidence regarding the effect of CME on prognosis has fundamental limitations that prevent it from being fully accepted. Methods: Patients who underwent radical resection for colon cancer were enrolled between November 2012 and March 2016. According to the principles of CME, patients were stratified into 2 groups based on intraoperative surgical fields and specimen photographs. The primary outcome was local recurrence-free survival (LRFS). The clinicopathological data and follow-up information were collected and recorded. The final follow-up date was April 2016. The trial was registered in ClinicalTrials.gov (identifier: NCT01724775). Results: There were 220 patients in the CME group and 110 patients in the noncomplete mesocolic excision (NCME) group. Baseline characteristics were well balanced. Compared with NCME, CME was associated with a greater number of total lymph nodes (24 vs 20, P = 0.002). Postoperative complications did not differ between the 2 groups. CME had a positive effect on LRFS compared with NCME (100.0% vs 90.2%, log-rank P < 0.001). Mesocolic dissection (100.0% vs 87.9%, log-rank P < 0.001) and nontumor deposits (97.2% vs 91.6%, log-rank P < 0.022) were also associated with improved LRFS. Conclusions: Our findings demonstrate that, compared with NCME, CME improves 3-year LRFS without increasing surgical risks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据