期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 11, 页码 4344-4348出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201915262
关键词
fibers; globular proteins; mechanical performance; microfluidics; crosslinking
资金
- Scientific Instrument Developing Project of the Chinese Academy of Sciences [ZDKYYQ20180001]
- K. C. Wong Education Foundation [GJTD-2018-09]
- National Natural Science Foundation of China [21704099, 21877104, 21834007, 21801235, 21907088]
- National Key R&D Program of China [2018YFA0902600]
Proteins used for the formation of light weight and mechanically strong biological fibers are typically composed of folded rigid and unfolded flexible units. In contrast to fibrous proteins, globular proteins are generally not regarded as a good candidate for fiber production due to their intrinsic structural defects. Thus, it is challenging to develop an efficient strategy for the construction of mechanically strong fibers using spherical proteins. Herein, we demonstrate the production of robust protein fibers from bovine serum albumin (BSA) using a microfluidic technique. Remarkably, the toughness of the fibers was up to 143 MJ m(-3), and after post-stretching treatment, their breaking strength increased to almost 300 MPa due to the induced long-range ordered structure in the fibers. The performance is comparable to or even higher than that of many recombinant spider silks or regenerated silkworm fibers. Thus, this work opens a new way for making biological fibers with high performance.
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