期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 11, 页码 4428-4433出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201913042
关键词
chlorination; manganese; photochemistry; radicals; synthetic methods
资金
- National Natural Science Foundation of China [21702230]
- Program for Jiangsu Province Innovative Research Team
- Double First-Class Project of China Pharmaceutical University [CPU2018GY35, CPU2018GF05]
A simple and efficient protocol to generate amidyl radicals from amine functionalities through a manganese-mediated atom-transfer reaction has been developed. This approach employs an earth-abundant and inexpensive manganese complex, Mn-2(CO)(10), as the catalyst and visible light as the energy input. Using this strategy, site-selective chlorination of unactivated C(sp(3))-H bonds of aliphatic amines and intramolecular/intermolecular chloroaminations of unactivated alkenes were readily realized under mild reaction conditions, thus providing efficient access to a range of synthetically valuable alkyl chlorides, chlorinated pyrrolidines, and vicinal chloroamine derivatives. These practical reactions exhibit a broad substrate scope and tolerate a wide array of functional groups, and complex molecules including various marketed drug derivatives.
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