期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 18, 页码 7188-7192出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202000174
关键词
C-H activation; chirality transfer; nitrones; rhodium; spirocycles
资金
- National Natural Science Foundation of China [21525208] Funding Source: Medline
Axial-to-central chirality transfer is an important strategy to construct chiral centers, where the axially chiral reagents are mostly limited to atropomerically stable ones. Reported herein is a Rh-III-catalyzed enantioselective spiroannulative synthesis of nitrones. The coupling proceeds via C-H arylation to give an atropomerically metastable biaryl, followed by intramolecular dearomative trapping under oxidative conditions with high degree of chirality transfer.
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