期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 19, 页码 7536-7541出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202000059
关键词
bioimaging; fluorogenic probes; glioma; monoamine oxidase A; two-photon fluorescence microscopy
Monoamine oxidases have two functionally distinct but structurally similar isoforms (MAO-A and MAO-B). The ability to differentiate them by using fluorescence detection/imaging technology is of significant biological relevance, but highly challenging with available chemical tools. Herein, we report the first MAO-A-specific two-photon fluorogenic probe (F1), capable of selective imaging of endogenous MAO-A enzymatic activities from a variety of biological samples, including MAO-A-expressing neuronal SY-SY5Y cells, the brain of tumor-bearing mice and human Glioma tissues by using two-photon fluorescence microscopy (TPFM) with minimal cytotoxicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据